Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Drug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy Pinto N; Ludeman SM; Dolan MEPharmacogenomics 2009[Dec]; 10 (12): 1897-903Cyclophosphamide is a cornerstone in the treatment of many pediatric and adult malignancies, as well as in the treatment of refractory autoimmune conditions. Genetic factors are thought to play a role in the interindividual variation in both response and toxicities associated with cyclophosphamide-based therapies. This drug focus reviews the most compelling studies conducted on the pharmacogenetics of cyclophosphamide-based therapies. Broader pharmacogenomic studies are needed and may reveal additional factors important in susceptibility to toxicity and/or response to therapy.|*Cyclophosphamide/administration & dosage/adverse effects/pharmacokinetics/therapeutic use[MESH]|*Pharmacogenetics[MESH]|Aldehyde Dehydrogenase/*genetics[MESH]|Cytochrome P-450 Enzyme System/*genetics[MESH]|Glutathione Transferase/*genetics[MESH]|Humans[MESH]|Polymorphism, Genetic[MESH] |
