Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Radiation-associated valvular disease Carlson RG; Mayfield WR; Normann S; Alexander JAChest 1991[Mar]; 99 (3): 538-45The prevalence of radiation-associated cardiac disease is increasing due to prolonged survival following mediastinal irradiation. Side effects of radiation include pericarditis, accelerated coronary artery disease, myocardial fibrosis and valvular injury. We evaluated the cases of three young patients with evidence of significant valvular disease following mediastinal irradiation. One patient underwent the first reported successful aortic and mitral valve replacement for radiation-associated valvular disease (RAVD) as well as concurrent coronary artery revascularization. A review of the literature revealed 35 reported cases of RAVD, with only one successful case of valve replacement that was limited to the aortic valve. Asymptomatic RAVD is diagnosed 11.5 years after mediastinal irradiation compared with 16.5 years for symptomatic patients, emphasizing that long-term follow-up is important for patients receiving mediastinal irradiation. This study defines a continuum of valvular disease following radiation that begins with mild asymptomatic valvular thickening and progresses to severe valvular fibrosis with hemodynamic compromise requiring surgical intervention.|Adolescent[MESH]|Adult[MESH]|Aortic Valve Stenosis/etiology[MESH]|Coronary Disease/etiology[MESH]|Endomyocardial Fibrosis/etiology[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Heart Valve Diseases/*etiology[MESH]|Humans[MESH]|Male[MESH]|Mediastinum/*radiation effects[MESH]|Mitral Valve Stenosis/etiology[MESH]|Myocardial Infarction/etiology[MESH]|Radiation Injuries/*etiology[MESH]|Radiotherapy/*adverse effects[MESH] |