Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Therapeutic methods used in patients with Eisenmenger syndrome Trojnarska O; Plaskota KCardiol J 2009[]; 16 (6): 500-6Patients with Eisenmenger syndrome form a small percentage of congenital heart disease patients. The rarity of this syndrome, combined with its complex pathophysiology, account for the insufficient understanding of the principles underlying its proper treatment. The main clinical symptoms are: cyanosis due to secondary erythrocytosis, resulting in increased blood viscosity, iron deficiency anemia (enhanced by unnecessary phlebotomies), blood clotting disturbances, heart failure and serious supraventricular and ventricular arrhythmias. Recent decades have seen developments in pulmonary hypertension pathophysiology which have led to the introduction of new groups of drugs: prostacycline analogs (Epoprostenol, Treprostinil, Beraprost, Illoprost), phosphodiesterase inhibitors (Sildenafil, Tadalafil), endothelin receptor antagonists (Bosentan, Sitaxantan, Ambrisentan) and nitric oxide. These drugs should be administered to patients in III-IV NYHA class. Despite successful early results, the therapeutic effect on patients with Eisenmenger syndrome has not been conclusively established. Our therapeutic efforts should be directed mainly towards preventing complications. As a rule, we should avoid agents with no established therapeutic efficacy and try to alleviate symptoms without any additional risk, so as not to disrupt the existing clinical balance.|Anemia, Iron-Deficiency/etiology/prevention & control[MESH]|Antihypertensive Agents/therapeutic use[MESH]|Arrhythmias, Cardiac/etiology/prevention & control[MESH]|Blood Coagulation Disorders/etiology/prevention & control[MESH]|Blood Viscosity[MESH]|Cyanosis/etiology/prevention & control[MESH]|Eisenmenger Complex/complications/diagnosis/drug therapy/etiology/*physiopathology/*therapy[MESH]|Endothelin Receptor Antagonists[MESH]|Female[MESH]|Heart Defects, Congenital/complications/physiopathology[MESH]|Humans[MESH]|Hypertension, Pulmonary/etiology/prevention & control[MESH]|Male[MESH]|Nitric Oxide/therapeutic use[MESH]|Phosphodiesterase Inhibitors/therapeutic use[MESH]|Polycythemia/etiology/prevention & control[MESH]|Pregnancy[MESH]|Pregnancy Complications, Cardiovascular/etiology/prevention & control[MESH]|Prostaglandins I/therapeutic use[MESH]|Risk Reduction Behavior[MESH]|Treatment Outcome[MESH] |