Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Regulation of hypoxia-inducible genes by PGC-1 alpha Shoag J; Arany ZArterioscler Thromb Vasc Biol 2010[Apr]; 30 (4): 662-6Atmospheric oxygen appeared approximately 2.3 billion years ago and sustains most complex life on earth. As mitochondria evolved to harness the energy in oxygen, systems developed to sense and respond to local oxygen concentrations and metabolic conditions. For more than a decade, research has focused on hypoxia-inducible factor 1 (HIF1), a key component of the eukaryotic oxygen-response system. Recently, evidence for other systems has also surfaced. One of these systems involves the PGC-1 alpha coactivator, a powerful transcriptional regulator of mitochondria and oxidative metabolic programs. This brief review will focus on this burgeoning role for PGC-1 alpha and will highlight the many questions that remain unanswered.|*Neovascularization, Physiologic/genetics[MESH]|*Signal Transduction/genetics[MESH]|Animals[MESH]|Blood Vessels/*metabolism/physiopathology[MESH]|Cell Hypoxia[MESH]|Gene Expression Regulation[MESH]|Heat-Shock Proteins/genetics/*metabolism[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1/genetics/*metabolism[MESH]|Ischemia/genetics/metabolism/physiopathology[MESH]|Mice[MESH]|Mitochondria/*metabolism[MESH]|Oxygen/*metabolism[MESH]|Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha[MESH]|Reactive Oxygen Species/metabolism[MESH]|Trans-Activators/genetics/*metabolism[MESH]|Transcription Factors/genetics/*metabolism[MESH]|Transcriptional Activation[MESH] |
