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lüll Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development Pechous RD; McCarthy TR; Zahrt TCMicrobiol Mol Biol Rev 2009[Dec]; 73 (4): 684-711Francisella tularensis is a facultative intracellular gram-negative pathogen and the etiological agent of the zoonotic disease tularemia. Recent advances in the field of Francisella genetics have led to a rapid increase in both the generation and subsequent characterization of mutant strains exhibiting altered growth and/or virulence characteristics within various model systems of infection. In this review, we summarize the major properties of several Francisella species, including F. tularensis and F. novicida, and provide an up-to-date synopsis of the genes necessary for pathogenesis by these organisms and the determinants that are currently being targeted for vaccine development.|*Francisella tularensis/pathogenicity/physiology[MESH]|*Tularemia/immunology/microbiology/prevention & control[MESH]|Animals[MESH]|Bacterial Vaccines/*therapeutic use[MESH]|Genes, Bacterial[MESH]|Host-Pathogen Interactions[MESH]|Humans[MESH]|Vaccination/trends[MESH]|Virulence[MESH]|Virulence Factors/genetics/metabolism[MESH] |