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lüll Bioinformatic approaches for the structure and function of membrane proteins Nam HJ; Jeon J; Kim SBMB Rep 2009[Nov]; 42 (11): 697-704Membrane proteins play important roles in the biology of the cell, including intercellular communication and molecular transport. Their well-established importance notwithstanding, the high-resolution structures of membrane proteins remain elusive due to difficulties in protein expression, purification and crystallization. Thus, accurate prediction of membrane protein topology can increase the understanding of membrane protein function. Here, we provide a brief review of the diverse computational methods for predicting membrane protein structure and function, including recent progress and essential bioinformatics tools. Our hope is that this review will be instructive to users studying membrane protein biology in their choice of appropriate bioinformatics methods.|*Computational Biology[MESH]|Biological Evolution[MESH]|Membrane Proteins/*chemistry/genetics/*physiology[MESH]|Structure-Activity Relationship[MESH] |