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lüll From genes to proteins in mendelian Parkinson s disease: an overview Pirkevi C; Lesage S; Brice A; Basak ANAnat Rec (Hoboken) 2009[Dec]; 292 (12): 1893-901Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. A progressive movement disorder typified by the production of bradykinesia, tremor, rigidity, and impairment of postural reflexes, PD is characterized by a depletion of dopamine in the striatum. For the last decade, several Mendelian forms of PD have been identified. Mutations in these genes potentially lead to autosomal dominant (alpha-synuclein and LRRK2), or autosomal recessive PD (Parkin, PINK1, DJ1, and ATP13A2). This article will spotlight these six distinct genes unambiguously associated with Mendelian PD and the function of their encoded proteins.|Animals[MESH]|Gene Expression Regulation/*genetics[MESH]|Genetic Predisposition to Disease/*genetics[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/genetics[MESH]|Leucine-Rich Repeat Serine-Threonine Protein Kinase-2[MESH]|Nerve Tissue Proteins/*genetics/*metabolism[MESH]|Oncogene Proteins/genetics[MESH]|Parkinson Disease/*genetics/*metabolism/physiopathology[MESH]|Protein Deglycase DJ-1[MESH]|Protein Kinases/genetics[MESH]|Protein Serine-Threonine Kinases/genetics[MESH]|Ubiquitin-Protein Ligases/genetics[MESH]|alpha-Synuclein/genetics[MESH] |