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lüll Resveratrol: a multifunctional compound improving endothelial function Editorial to: "Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats" by S Soylemez et al Li H; Forstermann UCardiovasc Drugs Ther 2009[Dec]; 23 (6): 425-9The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively.|Acetylation/drug effects[MESH]|Antioxidants/*pharmacology[MESH]|Endothelium, Vascular/*drug effects[MESH]|Humans[MESH]|Nitric Oxide Synthase Type III/*drug effects/metabolism[MESH]|Nitric Oxide/*biosynthesis[MESH]|Phosphorylation/drug effects[MESH]|Receptors, Estrogen/metabolism[MESH]|Resveratrol[MESH]|Sex Factors[MESH]|Stilbenes/*pharmacology[MESH]|Vasodilation/drug effects[MESH]|Wine[MESH] |