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Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy Beloueche-Babari M; Chung YL; Al-Saffar NM; Falck-Miniotis M; Leach MOBr J Cancer 2010[Jan]; 102 (1): 1-7Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use.|*Drug Delivery Systems[MESH]|Angiogenesis Inhibitors/pharmacology/therapeutic use[MESH]|Animals[MESH]|Antineoplastic Agents/*pharmacology/therapeutic use[MESH]|Biomarkers[MESH]|Choline/metabolism[MESH]|Drug Monitoring/*methods[MESH]|Energy Metabolism/drug effects[MESH]|Enzyme Inhibitors/pharmacology/therapeutic use[MESH]|Histone Deacetylases/metabolism[MESH]|Humans[MESH]|Magnetic Resonance Spectroscopy/*methods[MESH]|Neoplasm Proteins/antagonists & inhibitors/metabolism[MESH]|Neoplasms/drug therapy/*metabolism[MESH]|Phospholipids/metabolism[MESH]|Protein Kinases/metabolism[MESH]|Signal Transduction/*drug effects[MESH]|Translational Research, Biomedical[MESH]|Tumor Cells, Cultured/drug effects/metabolism[MESH]|Xenograft Model Antitumor Assays[MESH] |
