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  • Estrogen and xenoestrogens in breast cancer
  • Fernandez SV; Russo J
  • Toxicol Pathol 2010[Jan]; 38 (1): 110-22
  • There is growing concern that estrogenic environmental compounds that act as endocrine-disrupting chemicals might potentially have adverse effects on hormone-sensitive organs such as the breast. This concern is further fueled by evidence indicating that natural estrogens, specifically 17beta-estradiol, are important factors in the initiation and progression of breast cancer. We have developed an in vitro-in vivo model in which we have demonstrated the carcinogenicity of E2 in human breast epithelial cells MCF-10F. Hypermethylation of NRG1, STXBP6, BMP6, CSS3, SPRY1, and SNIP were found at different progression stages in this model. The use of this powerful and unique model has provided a tool for exploring whether bisphenol A and butyl benzyl phthalate have relevance in the initiation of breast cancer. These studies provide firsthand evidence that the natural estrogen 17beta-estradiol and xenoestrogenic substances like bisphenol A are able to induce neoplastic transformation in human breast epithelial cells.
  • |Benzhydryl Compounds[MESH]
  • |Breast Neoplasms/*chemically induced[MESH]
  • |Cell Transformation, Neoplastic/*chemically induced[MESH]
  • |DNA (Cytosine-5-)-Methyltransferase 1[MESH]
  • |DNA (Cytosine-5-)-Methyltransferases/analysis[MESH]
  • |DNA Methylation[MESH]
  • |Epigenesis, Genetic[MESH]
  • |Estradiol/*toxicity[MESH]
  • |Female[MESH]
  • |Gene Silencing[MESH]
  • |Humans[MESH]
  • |Phenols/*toxicity[MESH]
  • |Phthalic Acids/*toxicity[MESH]





  • *{{pmid19933552}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=19933552 Estrogen and xenoestrogens in breast cancer ]</b> Toxicol Pathol 2010; 38(1) ; 110-22 Fernandez SV; Russo J

        *19933552*

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    Toxicol Pathol

    110 1.38 2010