Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis Benchabane H; Ahmed YAdv Exp Med Biol 2009[]; 656 (ä): 75-84The adenomatous polyposis coli (APC) tumor suppressor is an essential negative regulator in the evolutionarily conserved Wnt/Wingless (Wg) signal transduction pathway. During normal development, Wnt signaling is required not only to induce cell proliferation and cell fate specification, but also to induce apoptotic cell death. However in some malignant states triggered by APC loss, inappropriate activation of Wnt signaling promotes cell survival and inhibits cell death, indicating that the cellular response to APC loss and Wnt signaling is highly dependent on cell context. This chapter summarizes our current understanding of the role of APC and Wnt signaling in the regulation of apoptosis, based upon studies from fly and mouse in vivo models, as well as cultured carcinoma cells.|Adenomatous Polyposis Coli Protein/*metabolism[MESH]|Animals[MESH]|Apoptosis/*physiology[MESH]|Carcinoma, Hepatocellular/metabolism/pathology[MESH]|Colorectal Neoplasms/metabolism/pathology[MESH]|Genes, APC[MESH]|Humans[MESH]|Liver Neoplasms/metabolism/pathology[MESH]|Mice[MESH]|Mutation[MESH]|Signal Transduction[MESH]|Wnt Proteins/*metabolism[MESH] |