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lüll Endovascular treatment of very small (3 mm or smaller) intracranial aneurysms: report of a consecutive series and a meta-analysis Brinjikji W; Lanzino G; Cloft HJ; Rabinstein A; Kallmes DFStroke 2010[Jan]; 41 (1): 116-21BACKGROUND AND PURPOSE: We performed a meta-analysis of published studies on the endovascular treatment of very small intracranial aneurysms, including 71 patients treated at our institution. METHODS: We conducted a computerized MEDLINE search of the literature for reports on the treatment of intracranial aneurysms with a maximum dimension of =3 mm by using the search terms "small," "tiny," "intracranial aneurysm," "endovascular," and "coil." A total of 7 studies, including our institution's consecutive case series of 71 intracranial aneurysms, were included in this study. We extracted information regarding intraoperative complications, procedural mortality and morbidity, immediate- and long-term angiographic outcomes, and retreatment rate. The meta-analysis was performed with the statistical package Comprehensive Meta-Analysis. RESULTS: Approximately 61% of the aneurysms in this meta-analysis presented as ruptured, whereas 39% of the aneurysms were unruptured. Procedural rupture rates for very small aneurysms was 8.3% (95% CI, 6.0% to 11.4%). The mortality rate due to procedural rupture was 2.4% (95% CI, 1.2% to 4.7%). The morbidity rate due to thromboembolic complications was 1.9% (95% CI, 0.9% to 3.9%). Subarachnoid hemorrhage within 1 month of treatment occurred in 1.6% (95% CI, 0.6% to 3.7%) of cases. There was no statistically significant difference between unruptured and ruptured aneurysms for any of these outcomes. CONCLUSIONS: Our meta-analysis suggests that treatment of very small aneurysms is feasible and effective in >90% of treated aneurysms. However, the risk of periprocedural rupture is higher than that reported for larger aneurysms. Similarly, the combined rate of periprocedural mortality and morbidity is not negligible (7.3%) and should be considered when considering the best therapeutic option for these aneurysms.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Intracranial Aneurysm/diagnosis/*pathology/*therapy[MESH]|Intraoperative Complications/diagnosis/pathology/prevention & control[MESH]|Male[MESH]|Middle Aged[MESH]|Neurosurgical Procedures/adverse effects[MESH]|Retrospective Studies[MESH]|Treatment Outcome[MESH] |