Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling Bankaitis VA; Mousley CJ; Schaaf GTrends Biochem Sci 2010[Mar]; 35 (3): 150-60Lipid signaling pathways define central mechanisms for cellular regulation. Productive lipid signaling requires an orchestrated coupling between lipid metabolism, lipid organization and the action of protein machines that execute appropriate downstream reactions. Using membrane trafficking control as primary context, we explore the idea that the Sec14-protein superfamily defines a set of modules engineered for the sensing of specific aspects of lipid metabolism and subsequent transduction of 'sensing' information to a phosphoinositide-driven 'execution phase'. In this manner, the Sec14 superfamily connects diverse territories of the lipid metabolome with phosphoinositide signaling in a productive 'crosstalk' between these two systems. Mechanisms of crosstalk, by which non-enzymatic proteins integrate metabolic cues with the action of interfacial enzymes, represent unappreciated regulatory themes in lipid signaling.|Animals[MESH]|Cell Membrane/chemistry/metabolism[MESH]|Lipid Metabolism/*physiology[MESH]|Models, Molecular[MESH]|Phosphatidylinositol Phosphates/metabolism[MESH]|Phosphatidylinositols/metabolism[MESH]|Phospholipid Transfer Proteins/chemistry/genetics/*metabolism[MESH]|Phosphotransferases (Alcohol Group Acceptor)/metabolism[MESH]|Protein Structure, Tertiary[MESH]|Saccharomyces cerevisiae Proteins/chemistry/genetics/*metabolism[MESH]|Signal Transduction/*physiology[MESH] |