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The role of glucagon-like peptide 1 in glucose homeostasis and in other aspects of human physiology Franek E; Gajos G; Gumprecht J; Kretowski A; Zahorska-Markiewicz B; Malecki MTPol Arch Med Wewn 2009[Nov]; 119 (11): 743-51This paper reviews the structure, function, and pathophysiology of glucagon-like peptide 1 (GLP-1). It describes the physiology and pathophysiology of the incretin axis, of which GLP-1 is a component, as well as the biosynthesis, secretion, activity, and degradation of this intestinal hormone. Effects of GLP-1 on the endocrine function of the pancreas, cardiovascular system, central nervous system, and on water-electrolyte balance have been also presented.|Animals[MESH]|Cardiovascular System/metabolism[MESH]|Central Nervous System/physiology[MESH]|Gastric Emptying/physiology[MESH]|Glucagon-Like Peptide 1/*metabolism[MESH]|Homeostasis/*physiology[MESH]|Humans[MESH]|Pancreas/physiology[MESH]|Receptors, Glucagon/metabolism/*physiology[MESH]|Water-Electrolyte Balance/physiology[MESH] |
