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Siah proteins: novel drug targets in the Ras and hypoxia pathways House CM; Moller A; Bowtell DDCancer Res 2009[Dec]; 69 (23): 8835-8The Siah (seven in absentia homolog) family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Siah family members have been reported to function in Ras, estrogen, DNA-damage, and hypoxia response pathways. Although earlier reports implicated Siah proteins as tumor suppressors, recent studies in mouse models have shown that Siah inhibition impairs tumor growth and metastasis. Given their central role in oncogenic and angiogenic pathways, Siah proteins are attractive novel therapeutic targets in cancer.|Animals[MESH]|Antineoplastic Agents/*pharmacology[MESH]|Cell Hypoxia/drug effects/physiology[MESH]|Drug Delivery Systems[MESH]|Humans[MESH]|Neoplasms/drug therapy/metabolism[MESH]|Nuclear Proteins/*antagonists & inhibitors/*metabolism[MESH]|Seven in Absentia Proteins[MESH]|Ubiquitin-Protein Ligases/*antagonists & inhibitors/*metabolism[MESH]|ras Proteins/*metabolism[MESH] |
