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Mitochondrial-targeted fluorescent probes for reactive oxygen species Dickinson BC; Srikun D; Chang CJCurr Opin Chem Biol 2010[Feb]; 14 (1): 50-6As the primary consumers of oxygen within all aerobic organisms, mitochondria are a major source of cellular reactive oxygen species (ROS) derived from the in vivo chemistry of oxygen metabolism. Mitochondrial ROS have been traditionally implicated in aging and in a variety of pathologies, including cancer, neurodegeneration, and diabetes, but recent studies also link controlled mitochondrial ROS fluxes to cell regulation and signaling events. Progress in the development of mitochondrial-targeted fluorescent small-molecule indicators that detect specific ROS with high selectivity offers a promising approach for interrogating mitochondrial ROS production, trafficking, and downstream biological effects.|Fluorescent Dyes/chemistry/*metabolism[MESH]|Mitochondria/*metabolism[MESH]|Molecular Imaging/*methods[MESH]|Molecular Weight[MESH]|Reactive Oxygen Species/chemistry/*metabolism[MESH] |
