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lüll Beyond oncology--application of HPMA copolymers in non-cancerous diseases Liu XM; Miller SC; Wang DAdv Drug Deliv Rev 2010[Feb]; 62 (2): 258-71Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.|*Nanomedicine/methods[MESH]|Acrylamides/chemical synthesis/chemistry/*therapeutic use[MESH]|Animals[MESH]|Arthritis, Rheumatoid/drug therapy[MESH]|Humans[MESH]|Neoplasms/drug therapy[MESH]|Osteoporosis/drug therapy[MESH]|Polymers/chemical synthesis/chemistry/*therapeutic use[MESH] |