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lüll The role of hepcidin in iron metabolism Nemeth E; Ganz TActa Haematol 2009[]; 122 (2-3): 78-86Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory.|Antimicrobial Cationic Peptides/biosynthesis/chemistry/*physiology[MESH]|Hepcidins[MESH]|Homeostasis/physiology[MESH]|Humans[MESH]|Iron/*metabolism[MESH]|Models, Molecular[MESH]|Protein Conformation[MESH] |