Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors Duffy A; Kummar STarget Oncol 2009[Dec]; 4 (4): 267-73The Raf-mitogen activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) protein kinase signaling cascade is an important intracellular pathway whose activation influences many fundamental cellular processes and whose aberrancy is associated with cancer cell growth. In addition to activation from within by, for example, Raf mutations, this pathway is frequently activated from above by mutated Ras or epidermal growth factor receptor (EGFR). Given the near ubiquity of derangements affecting at least part of this network in cancer, there is a strong and clear rationale for interrupting it. In recent times, in colorectal and lung cancer, Ras and EGFR mutant status have been shown to be critically important and mutually exclusive predictors of response to anti-EGFR therapies. These developments underline the importance of targeting downstream effectors, and MEK inhibition has been the subject of intense scientific and clinical research for some time now. This article reviews the current status of MEK inhibitors with regard to their clinical development.|*Drug Delivery Systems[MESH]|Cell Line, Tumor[MESH]|Drug Resistance, Neoplasm/*physiology[MESH]|ErbB Receptors[MESH]|Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors[MESH]|Humans[MESH]|Lung Neoplasms/enzymology/*metabolism[MESH]|MAP Kinase Signaling System/drug effects[MESH]|Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors[MESH]|Mitogen-Activated Protein Kinases/*antagonists & inhibitors[MESH]|NF-kappa B/metabolism[MESH]|Proto-Oncogene Proteins c-bcl-2/metabolism[MESH]|STAT3 Transcription Factor/physiology[MESH] |