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lüll SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended?Rozin APArthritis Res Ther 2009[]; 11 (6): 131SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assmann et al. is a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Randomized control studies are needed to confirm the effects of antibiotic therapy.|Acquired Hyperostosis Syndrome/drug therapy/*immunology/*microbiology[MESH]|Animals[MESH]|Anti-Bacterial Agents/therapeutic use[MESH]|Antirheumatic Agents/therapeutic use[MESH]|Humans[MESH]|Propionibacterium acnes/immunology[MESH] |