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lüll Management and outcome of two pregnancies in a woman with craniodiaphyseal dysplasia Thurnau GR; Stein SA; Schaefer GB; Morgan MA; Wall JF; Rennert OMAm J Perinatol 1991[Jan]; 8 (1): 56-61Hyperostotic bone dysplasias are characterized by progressive hyperostosis and sclerosis of the cranium and facial bones. As a result of progressive bony overgrowth, intracranial pressure may increase and lead to brain and nerve compression, cranial nerve palsies, and an increased incidence of seizures. The long bones often exhibit defective modeling as well as variable degrees of metaphyseal and diaphyseal hyperostosis. In addition, the axial skeleton (including the pelvis) is often hyperostotic and sclerotic. The clinical features of these disorders may have relevance to the outcome of pregnancy; however, there are no reports on the management and pregnancy outcome of patients affected with hyperostotic bone disease. In this report, we describe the course of two pregnancies in a woman with craniodiaphyseal dysplasia (a rare craniotubular dysplasia). Prenatal assessment, method of delivery, choice of anesthesia, and neonatal management are discussed. Although this disorder is rare, the pathophysiologic considerations relevant to pregnancy outcome may be applicable to the management of pregnant women with other hyperostotic bone dysplasias.|*Pregnancy Outcome[MESH]|Adult[MESH]|Facial Bones/*abnormalities[MESH]|Female[MESH]|Humans[MESH]|Hyperostosis Frontalis Interna/complications/*genetics[MESH]|Infant[MESH]|Male[MESH]|Pedigree[MESH]|Pregnancy[MESH]|Pregnancy Complications/*therapy[MESH]|Skull/*abnormalities[MESH] |