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Pharmacotherapy of postpartum depression di Scalea TL; Wisner KLExpert Opin Pharmacother 2009[Nov]; 10 (16): 2593-607BACKGROUND: The prevalence and recurrence rates of postpartum depression (PPD) are 13 and 25%, respectively. Despite its detrimental impact on the health of the mother-infant dyad, there is a paucity of data in the literature regarding the efficacy of pharmacological treatment of PPD. OBJECTIVES: i) To review the literature on the use of antidepressants and hormonal supplements for the prevention and the treatment of PPD; ii) to give the authors' opinion on the current status of the pharmacological treatment of PPD; and iii) to discuss developments that are likely to be important in the future. METHODS: An electronic search was performed by using PubMed, Medline, and PsychINFO. Inclusion criteria were: i) empirical articles in peer-reviewed English-language journals; ii) well-validated measures of depression; and iii) a uniform scoring system for depression among the sample. RESULTS/CONCLUSION: The electronic search yielded a total of 19 articles (12 on treatment and 7 on prevention of PPD) with the following study designs: eight randomized clinical trials (six using placebo control and two using active control groups), and 11 open-label studies. The selection of the specific antidepressant for a woman with PPD should derive from a personalized risk-benefit analysis.|Antidepressive Agents/*therapeutic use[MESH]|Breast Feeding[MESH]|Depression, Postpartum/*drug therapy/prevention & control[MESH]|Female[MESH]|Humans[MESH]|Randomized Controlled Trials as Topic[MESH] |
