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lüll Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?Steinstraesser L; Kraneburg UM; Hirsch T; Kesting M; Steinau HU; Jacobsen F; Al-Benna SInt J Mol Sci 2009[Sep]; 10 (9): 3951-3970Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses. Both antimicrobial and/or immunomodulatory activities are an integral part of the process of innate immunity, which itself has many of the hallmarks of successful anti-infective therapies, namely rapid action and broad-spectrum antimicrobial activities. This gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections. This review details the role and activities of these peptides, and examines their applicability as development candidates for use against bacterial infections.|*Drug Resistance, Bacterial[MESH]|*Immunity, Innate[MESH]|Animals[MESH]|Anti-Bacterial Agents/pharmacology/therapeutic use[MESH]|Antimicrobial Cationic Peptides/*physiology[MESH]|Bacteria/drug effects/immunology[MESH]|Bacterial Infections/immunology/metabolism[MESH]|Host-Pathogen Interactions[MESH]|Humans[MESH] |