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lüll Use of hepadnavirus core proteins as vaccine platforms Whitacre DC; Lee BO; Milich DRExpert Rev Vaccines 2009[Nov]; 8 (11): 1565-73The first virus-like particle to be tested for use as a vaccine carrier was based on the hepatitis B virus nucleocapsid protein. This viral subunit, while not infectious on its own, is a 36-nm particle that is highly immunogenic during a natural infection. The self-assembly and high degree of immunogenicity is maintained when expressed as a recombinant protein and, moreover, can confer a high degree of immunogenicity on foreign antigens linked to the particle, either chemically or genetically. This review describes the current state of the hepadnaviral core protein as a vaccine carrier.|Carrier Proteins/*genetics/*immunology[MESH]|Hepatitis B Core Antigens/*genetics/*immunology[MESH]|Hepatitis B virus/*genetics[MESH]|Humans[MESH]|Recombinant Fusion Proteins/genetics/immunology[MESH]|Vaccines, Synthetic/genetics[MESH]|Vaccines, Virosome/genetics/immunology[MESH] |