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Immunotherapy of human cancers using gene modified T lymphocytes Vera JF; Brenner MK; Dotti GCurr Gene Ther 2009[Oct]; 9 (5): 396-408Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.|*Genetic Engineering[MESH]|*Immunotherapy[MESH]|Antigens/immunology[MESH]|Humans[MESH]|Neoplasms/*therapy[MESH]|T-Lymphocytes/*immunology[MESH] |
