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lüll Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells Wang L; de Zoeten EF; Greene MI; Hancock WWNat Rev Drug Discov 2009[Dec]; 8 (12): 969-81Classical zinc-dependent histone deacetylases (HDACs) catalyse the removal of acetyl groups from histone tails and also from many non-histone proteins, including the transcription factor FOXP3, a key regulator of the development and function of regulatory T cells. Many HDAC inhibitors are in cancer clinical trials, but a subset of HDAC inhibitors has important anti-inflammatory or immunosuppressive effects that might be of therapeutic benefit in immuno-inflammatory disorders or post-transplantation. At least some of these effects result from the ability of HDAC inhibitors to enhance the production and suppressive functions of FOXP3(+) regulatory T cells. Understanding which HDACs contribute to the regulation of the functions of regulatory T cells may further stimulate the development of new class- or subclass-specific HDAC inhibitors with applications beyond oncology.|Animals[MESH]|Drug Delivery Systems[MESH]|Drug Design[MESH]|Forkhead Transcription Factors/*metabolism[MESH]|Histone Deacetylase Inhibitors/*pharmacology[MESH]|Humans[MESH]|Immunologic Factors/*pharmacology[MESH]|Inflammation/drug therapy/immunology[MESH]|Organ Transplantation/methods[MESH]|T-Lymphocytes, Regulatory/drug effects/enzymology[MESH] |