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lüll The nuclear envelopathies and human diseases Chi YH; Chen ZJ; Jeang KTJ Biomed Sci 2009[Oct]; 16 (1): 96The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies.|Animals[MESH]|Cell Cycle[MESH]|Chromosomes/metabolism[MESH]|Cytoplasm/metabolism[MESH]|DNA Repair[MESH]|Gene Expression Profiling[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Lamin Type A/metabolism[MESH]|Lamin Type B/metabolism[MESH]|Mice[MESH]|Models, Biological[MESH]|Nuclear Envelope/*metabolism[MESH]|Nuclear Lamina/*metabolism[MESH]|Nuclear Pore Complex Proteins/metabolism[MESH] |