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lüll Prodromal myeloproliferative neoplasms: the 2008 WHO classification Kvasnicka HM; Thiele JAm J Hematol 2010[Jan]; 85 (1): 62-9The concept of prodromal chronic myeloproliferative neoplasms has been endorsed by the WHO classification implicating a stepwise evolution of disease. Histology of the bone marrow (BM) and borderline to mildly expressed clinical features play a pivotal role for diagnosing prefibrotic-early primary myelofibrosis. By lowering the platelet count for essential thrombocythemia and regarding BM morphology, early manifestations are tackled. Pre-polycythemic stages of polycythemia vera with a low hemoglobin level at onset are diagnosed by positive JAK2V617F mutation status, a low erythropoietin value, and characteristic BM features. The revised WHO classification incorporates hematological, morphological, and molecular-genetic parameters to generate a consensus-based working diagnosis.|Bone Marrow Examination[MESH]|Disease Progression[MESH]|Erythrocyte Volume[MESH]|Erythropoietin/blood[MESH]|Female[MESH]|Humans[MESH]|Janus Kinase 2/genetics[MESH]|Male[MESH]|Mutation[MESH]|Platelet Count[MESH]|Polycythemia Vera/diagnosis/*pathology[MESH]|Primary Myelofibrosis/diagnosis/*pathology[MESH]|Risk[MESH]|Thrombocythemia, Essential/diagnosis/*pathology[MESH]|World Health Organization[MESH] |