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  • The restless brain: attention-deficit hyperactivity disorder, resting-state functional connectivity, and intrasubject variability
  • Castellanos FX; Kelly C; Milham MP
  • Can J Psychiatry 2009[Oct]; 54 (10): 665-72
  • OBJECTIVES: To highlight recent advances in the conceptualization of attention-deficit hyperactivity disorder (ADHD) emerging from neuroimaging and endophenotypic approaches. METHODS: We selectively reviewed recent published literature on the phenomena of resting-state functional connectivity, intrasubject variability, and diffusion tensor imaging pertaining to ADHD. RESULTS: Recent advances based on the novel approach of resting-state functional connectivity appear to be highly promising and likely to link to studies of intrasubject variability. CONCLUSIONS: Endophenotypic fractionation may offer a means of addressing the complex heterogeneity of ADHD on the path to testable models of pathophysiology. Such models focusing on intrasubject variability, intrinsic brain activity, and reward-related processing are progressing rapidly.
  • |*Diffusion Magnetic Resonance Imaging[MESH]
  • |*Image Processing, Computer-Assisted[MESH]
  • |*Imaging, Three-Dimensional[MESH]
  • |Adult[MESH]
  • |Arousal/*physiology[MESH]
  • |Attention Deficit Disorder with Hyperactivity/*physiopathology[MESH]
  • |Attention/physiology[MESH]
  • |Brain Mapping[MESH]
  • |Brain/*physiopathology[MESH]
  • |Cerebral Cortex/physiopathology[MESH]
  • |Child[MESH]
  • |Dominance, Cerebral[MESH]
  • |Gyrus Cinguli/physiopathology[MESH]
  • |Humans[MESH]
  • |Individuality[MESH]
  • |Motivation[MESH]
  • |Nerve Net/*physiopathology[MESH]





  • *{{pmid19835673}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=19835673 The restless brain: attention-deficit hyperactivity disorder, resting-state functional connectivity, and intrasubject variability ]</b> Can J Psychiatry 2009; 54(10) ; 665-72 Castellanos FX; Kelly C; Milham MP

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    Can J Psychiatry

    665 10.54 2009