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lüll The restless brain: attention-deficit hyperactivity disorder, resting-state functional connectivity, and intrasubject variability Castellanos FX; Kelly C; Milham MPCan J Psychiatry 2009[Oct]; 54 (10): 665-72OBJECTIVES: To highlight recent advances in the conceptualization of attention-deficit hyperactivity disorder (ADHD) emerging from neuroimaging and endophenotypic approaches. METHODS: We selectively reviewed recent published literature on the phenomena of resting-state functional connectivity, intrasubject variability, and diffusion tensor imaging pertaining to ADHD. RESULTS: Recent advances based on the novel approach of resting-state functional connectivity appear to be highly promising and likely to link to studies of intrasubject variability. CONCLUSIONS: Endophenotypic fractionation may offer a means of addressing the complex heterogeneity of ADHD on the path to testable models of pathophysiology. Such models focusing on intrasubject variability, intrinsic brain activity, and reward-related processing are progressing rapidly.|*Diffusion Magnetic Resonance Imaging[MESH]|*Image Processing, Computer-Assisted[MESH]|*Imaging, Three-Dimensional[MESH]|Adult[MESH]|Arousal/*physiology[MESH]|Attention Deficit Disorder with Hyperactivity/*physiopathology[MESH]|Attention/physiology[MESH]|Brain Mapping[MESH]|Brain/*physiopathology[MESH]|Cerebral Cortex/physiopathology[MESH]|Child[MESH]|Dominance, Cerebral[MESH]|Gyrus Cinguli/physiopathology[MESH]|Humans[MESH]|Individuality[MESH]|Motivation[MESH]|Nerve Net/*physiopathology[MESH] |