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English Wikipedia
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Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature Woo VL; Landesberg R; Imel EA; Singer SR; Folpe AL; Econs MJ; Kim T; Harik LR; Jacobs TPOral Surg Oral Med Oral Pathol Oral Radiol Endod 2009[Dec]; 108 (6): 925-32Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that results in renal phosphate wasting with hypophosphatemia. In most cases, the underlying cause of TIO is a small mesenchymal neoplasm that is often difficult to detect, resulting in delayed diagnosis. One such neoplasm is the phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT), an unusual entity with unique morphologic and biochemical features. Most of these tumors are found at appendicular sites with only rare cases reported in the jaws. We describe a PMTMCT involving the mandible in a patient with a protracted history of osteomalacia. A review of the current literature is provided with emphasis on the clinical and histologic features, etiopathogenesis, and management of PMTMCT in the setting of TIO.|Adult[MESH]|Female[MESH]|Humans[MESH]|Hypophosphatemia/etiology/pathology/therapy[MESH]|Mandibular Neoplasms/*complications/pathology/surgery[MESH]|Mesenchymoma/*complications/pathology/surgery[MESH]|Neoplasms, Connective Tissue/*complications/pathology/surgery[MESH]|Osteomalacia/*etiology/pathology/therapy[MESH]|Paraneoplastic Syndromes/complications/*pathology/therapy[MESH] |
