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lüll Extracorporeal photo-apheresis for the treatment of steroid-resistant graft versus host disease Baird K; Wayne ASTransfus Apher Sci 2009[Dec]; 41 (3): 209-16Acute and chronic graft versus host disease are frequent and potentially severe complications of allogeneic hematopoietic stem cell transplantation and are among the leading causes of non-relapse transplant-related mortality. For patients with steroid refractory disease, prognosis is particularly poor and although a variety of treatment options are available, responses are commonly transient and the side effects often intolerable. Since it was first introduced for the treatment of cutaneous T-cell lymphoma, extracorporeal photo-apheresis has been utilized as an immunomodulatory therapy for certain autoimmune diseases and solid organ transplant rejection. Recently, extracorporeal photo-apheresis has become a promising alternative for patients with graft versus host disease with disabling or potentially lethal complications. Here we review the experience of extracorporeal photo-apheresis for the treatment of steroid refractory acute and chronic graft versus host disease based on the current literature.|*Drug Resistance[MESH]|Graft vs Host Disease/*therapy[MESH]|Hematopoietic Stem Cell Transplantation[MESH]|Humans[MESH]|Photopheresis/*methods[MESH]|Steroids/pharmacology/therapeutic use[MESH] |