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P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall Huo Y; Xia LTrends Cardiovasc Med 2009[May]; 19 (4): 140-5Leukocyte recruitment to the arterial vessel wall is the first step in the development of atherosclerotic lesions. Leukocyte homing in this event proceeds through a well-defined adhesion cascade, which includes tethering, rolling, adhesion, and transmigration. Selectins, including the P-, E-, and L-selectins, and their ligands mediate the initial tethering and rolling. Interactions between selectins and their ligands serve as a braking system to decelerate fast-flowing leukocytes from the central blood stream and enable them to adhere to and transmigrate underneath the activated endothelium. The best characterized ligand for selectins is P-selectin glycoprotein ligand-1, an extended homodimeric mucin on leukocytes that binds to all three selectins. Recent studies show that differential expression or glycosylation of P-selectin glycoprotein ligand-1 in different leukocytes mediates selective recruitment of different subsets of monocytes or lymphocytes to atherosclerotic arteries.|*Cell Adhesion[MESH]|*Leukocyte Rolling[MESH]|Animals[MESH]|Arteries/*immunology[MESH]|Atherosclerosis/*immunology[MESH]|Endothelium, Vascular/immunology[MESH]|Glycosylation[MESH]|Humans[MESH]|Inflammation Mediators/metabolism[MESH]|Inflammation/immunology[MESH]|Leukocytes/*immunology[MESH]|Ligands[MESH]|Membrane Glycoproteins/*metabolism[MESH]|Protein Processing, Post-Translational[MESH]|Selectins/*metabolism[MESH] |
