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lüll The clinical efficacy of artemether/lumefantrine (Coartem) Makanga M; Krudsood SMalar J 2009[Oct]; 8 Suppl 1 (Suppl 1): S5Current World Health Organization (WHO) guidelines for the treatment of uncomplicated falciparum malaria recommend the use of artemisinin-based combination therapy (ACT). Artemether/lumefantrine is an ACT prequalified by the WHO for efficacy, safety and quality, approved by Swissmedic in December 2008 and recently approved by the USA FDA. Coartem is a fixed-dose combination of artemether and lumefantrine. Its two components have different modes of action that provide synergistic anti-malarial activity. It is indicated for the treatment of infants, children and adults with acute, uncomplicated infection due to Plasmodium falciparum or mixed infections including P. falciparum. A formulation with improved palatability has been developed especially for children (Coartem Dispersible), which rapidly disperses in a small amount of water for ease of administration. The efficacy of the six-dose regimen of artemether/lumefantrine has been confirmed in many different patient populations around the world, consistently achieving 28-day PCR (polymerase chain reaction)-corrected cure rates of >95% in the evaluable population, rapidly clearing parasitaemia and fever, and demonstrating a significant gametocidal effect, even in areas of widespread parasite resistance to other antimalarials.|Africa[MESH]|Antimalarials/*therapeutic use[MESH]|Artemether, Lumefantrine Drug Combination[MESH]|Artemisinins/*therapeutic use[MESH]|Asia[MESH]|Drug Combinations[MESH]|Ethanolamines/*therapeutic use[MESH]|Fluorenes/*therapeutic use[MESH]|Humans[MESH]|Malaria/*drug therapy[MESH]|Polymerase Chain Reaction[MESH] |