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lüll Schizophrenia: a subcortical neurotransmitter imbalance syndrome?Carlsson M; Carlsson ASchizophr Bull 1990[]; 16 (3): 425-32Recent animal experiments suggest that glutamate plays a fundamental role in the control of psychomotor activity. This is illustrated by the finding that even in the virtually complete absence of dopamine, a marked behavioral activation is produced in mice following suppression of glutamatergic neurotransmission. This article discusses the possibility that a deficient activity within the cortico-striatal glutamatergic pathway is an important pathophysiological component in some cases of schizophrenia and that glutamatergic agonists may prove beneficial in this disorder. In a broader perspective, schizophrenia may be looked upon as a syndrome induced by a neurotransmitter imbalance in a feedback-regulated system, where dopamine and glutamate play a crucial role in controlling arousal and the processing of signals from the outer world to the cerebral cortex via the thalamus.|*Schizophrenic Psychology[MESH]|Animals[MESH]|Arousal/physiology[MESH]|Cerebral Cortex/*physiopathology[MESH]|Corpus Striatum/*physiopathology[MESH]|Dopamine/*physiology[MESH]|Glutamates/*physiology[MESH]|Glutamic Acid[MESH]|Humans[MESH]|Neural Pathways/physiopathology[MESH]|Receptors, Dopamine/physiology[MESH]|Receptors, Glutamate[MESH]|Receptors, Neurotransmitter/physiology[MESH]|Schizophrenia/*physiopathology[MESH] |