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Lox-1: the multifunctional receptor underlying cardiovascular dysfunction Ogura S; Kakino A; Sato Y; Fujita Y; Iwamoto S; Otsui K; Yoshimoto R; Sawamura TCirc J 2009[Nov]; 73 (11): 1993-9Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces morphological changes for atheroma-formation. Lectin-like oxidized LDL receptor-1 (LOX-1) was identified as the receptor for oxLDL that was thought to be a major cause of endothelial dysfunction. LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but also to atherosclerotic-plaque formation, myocardial infarction and intimal thickening after balloon injury. Recent findings on the genetics of LOX-1 and the methodology to detect it and its ligands would further facilitate the examination of the receptor's pathophysiological contribution in atherosclerosis. Furthermore, LOX-1-related tools might open new gateways from diagnosis to therapeutics for cardiovascular diseases.|Animals[MESH]|C-Reactive Protein/physiology[MESH]|Cardiovascular Diseases/etiology/genetics/*physiopathology[MESH]|Humans[MESH]|Kidney/injuries/physiopathology[MESH]|Ligands[MESH]|Models, Cardiovascular[MESH]|Models, Molecular[MESH]|Myocardial Infarction/physiopathology[MESH]|Scavenger Receptors, Class E/chemistry/genetics/*physiology[MESH]|Signal Transduction[MESH] |
