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  • The role of let-7 in cell differentiation and cancer
  • Boyerinas B; Park SM; Hau A; Murmann AE; Peter ME
  • Endocr Relat Cancer 2010[Mar]; 17 (1): F19-36
  • MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene expression at the translational level. Current evidence suggests that a significant portion of the human genome is regulated by microRNAs, and many reports have demonstrated that microRNA expression is deregulated in human cancer. The let-7 family of microRNAs, first discovered in Caenorhabditis elegans, is functionally conserved from worms to humans. The human let-7 family contains 13 members located on nine different chromosomes, and many human cancers have deregulated let-7 expression. A growing body of evidence suggests that restoration of let-7 expression may be a useful therapeutic option in cancers, where its expression has been lost. In this review, we discuss the role of let-7 in normal development and differentiation, and provide an overview of the relationship between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the relationship between let-7 and drug sensitivity are highlighted.
  • |*Gene Expression Regulation, Neoplastic[MESH]
  • |Animals[MESH]
  • |Antineoplastic Agents/pharmacokinetics[MESH]
  • |Caenorhabditis elegans/genetics/growth & development/physiology[MESH]
  • |Cell Differentiation/*physiology[MESH]
  • |Cell Transformation, Neoplastic/*genetics[MESH]
  • |Drosophila melanogaster/genetics/growth & development[MESH]
  • |Drug Resistance, Neoplasm/genetics[MESH]
  • |Evolution, Molecular[MESH]
  • |Female[MESH]
  • |Gene Expression Regulation, Developmental[MESH]
  • |Humans[MESH]
  • |Larva[MESH]
  • |Male[MESH]
  • |MicroRNAs/genetics/*physiology/therapeutic use[MESH]
  • |Multigene Family[MESH]
  • |Neoplasms/*genetics/pathology/therapy[MESH]
  • |RNA, Neoplasm/genetics[MESH]
  • |Species Specificity[MESH]

  • *{{pmid19779035}}
    *<b>[ The role of let-7 in cell differentiation and cancer ]</b> Endocr Relat Cancer 2010; 17(1) ; F19-36 Boyerinas B; Park SM; Hau A; Murmann AE; Peter ME


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    Endocr Relat Cancer

    F19 1.17 2010