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lüll The role of let-7 in cell differentiation and cancer Boyerinas B; Park SM; Hau A; Murmann AE; Peter MEEndocr Relat Cancer 2010[Mar]; 17 (1): F19-36MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene expression at the translational level. Current evidence suggests that a significant portion of the human genome is regulated by microRNAs, and many reports have demonstrated that microRNA expression is deregulated in human cancer. The let-7 family of microRNAs, first discovered in Caenorhabditis elegans, is functionally conserved from worms to humans. The human let-7 family contains 13 members located on nine different chromosomes, and many human cancers have deregulated let-7 expression. A growing body of evidence suggests that restoration of let-7 expression may be a useful therapeutic option in cancers, where its expression has been lost. In this review, we discuss the role of let-7 in normal development and differentiation, and provide an overview of the relationship between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the relationship between let-7 and drug sensitivity are highlighted.|*Gene Expression Regulation, Neoplastic[MESH]|Animals[MESH]|Antineoplastic Agents/pharmacokinetics[MESH]|Caenorhabditis elegans/genetics/growth & development/physiology[MESH]|Cell Differentiation/*physiology[MESH]|Cell Transformation, Neoplastic/*genetics[MESH]|Drosophila melanogaster/genetics/growth & development[MESH]|Drug Resistance, Neoplasm/genetics[MESH]|Evolution, Molecular[MESH]|Female[MESH]|Gene Expression Regulation, Developmental[MESH]|Humans[MESH]|Larva[MESH]|Male[MESH]|MicroRNAs/genetics/*physiology/therapeutic use[MESH]|Multigene Family[MESH]|Neoplasms/*genetics/pathology/therapy[MESH]|RNA, Neoplasm/genetics[MESH]|Species Specificity[MESH] |