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MicroRNAs and prostate cancer Coppola V; De Maria R; Bonci DEndocr Relat Cancer 2010[Mar]; 17 (1): F1-17Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has documented the role of microRNAs as new broad-spectrum oncogenes or tumour suppressor genes, thus their use as diagnostic, prognostic and therapeutic biomolecules is envisaged. This review extensively and critically summarizes the current knowledge about microRNA deregulation in prostate cancer disease, underlining present limits and future perspectives.|*Gene Expression Regulation, Neoplastic[MESH]|Adenocarcinoma/diagnosis/*genetics/therapy[MESH]|Androgens[MESH]|Cell Transformation, Neoplastic/genetics[MESH]|Disease Progression[MESH]|Gene Expression Profiling[MESH]|Genes, Tumor Suppressor[MESH]|Humans[MESH]|Male[MESH]|MicroRNAs/analysis/*genetics[MESH]|Neoplasm Invasiveness/genetics[MESH]|Neoplasm Proteins/biosynthesis/genetics[MESH]|Neoplasms, Hormone-Dependent/diagnosis/genetics/therapy[MESH]|Prognosis[MESH]|Prostatic Neoplasms/diagnosis/*genetics/therapy[MESH]|Proto-Oncogene Proteins c-myc/physiology[MESH]|RNA, Neoplasm/*genetics[MESH] |
