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lüll Control of cell growth by the SCF and APC/C ubiquitin ligases Skaar JR; Pagano MCurr Opin Cell Biol 2009[Dec]; 21 (6): 816-24The ubiquitin-proteasome system plays key roles in the control of cell growth. The cell cycle, in particular, is highly regulated by the functions of the SCF and APC/C ubiquitin ligases, and perturbation of their function can result in tumorigenesis. Although the SCF and APC/C complexes are well established in growth control pathways, many aspects of their function remain unknown. Recent studies have shed light on the mechanism of SCF-mediated ubiquitination and new functions for the SCF complex and APC/C. Our expanding understanding of the roles of the SCF and APC/C complexes highlight the potential for targeted molecular therapies.|Animals[MESH]|Cell Cycle Proteins/genetics/metabolism[MESH]|Cell Cycle/physiology[MESH]|Cullin Proteins[MESH]|Humans[MESH]|Models, Biological[MESH]|Proteasome Endopeptidase Complex/genetics/metabolism[MESH]|SKP Cullin F-Box Protein Ligases/genetics/*metabolism[MESH]|Signal Transduction[MESH]|Ubiquitin C/genetics/*metabolism[MESH]|Ubiquitin-Protein Ligases/genetics/*metabolism[MESH]|Ubiquitin/genetics/metabolism[MESH] |