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Mechanisms of chromosomal rearrangements in solid tumors: the model of papillary thyroid carcinoma Gandhi M; Evdokimova V; Nikiforov YEMol Cell Endocrinol 2010[May]; 321 (1): 36-43Thyroid cancer, and its most common type, papillary carcinoma, frequently have chromosomal rearrangements and therefore represent a good model for the understanding of mechanisms of chromosomal rearrangements in solid tumors. Several types of rearrangement known to occur in thyroid cancer, including RET/PTC, NTRK1 and BRAF/AKAP9, are more common in radiation-associated thyroid tumors and RET/PTC can be induced experimentally by exposing human thyroid cells to ionizing radiation. In this review, the molecular mechanisms of generation of RET/PTC and other chromosomal rearrangements are discussed, with the emphasis on the role of nuclear architecture and interphase gene proximity in the generation of intrachromosomal rearrangements in thyroid cells.|*Chromosome Aberrations[MESH]|*Models, Biological[MESH]|Base Sequence[MESH]|Carcinoma, Papillary/*genetics/pathology[MESH]|DNA Repair/genetics[MESH]|Gene Rearrangement/*genetics[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Thyroid Neoplasms/*genetics/pathology[MESH] |
