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lüll Intracellular assembly and trafficking of MHC class I molecules Donaldson JG; Williams DBTraffic 2009[Dec]; 10 (12): 1745-52The presentation of antigenic peptides by class I molecules of the major histocompatibility complex begins in the endoplasmic reticulum (ER) where the co-ordinated action of molecular chaperones, folding enzymes and class I-specific factors ensures that class I molecules are loaded with high-affinity peptide ligands that will survive prolonged display at the cell surface. Once assembled, class I molecules are released from the quality-control machinery of the ER for export to the plasma membrane where they undergo dynamic endocytic cycling and turnover. We review recent progress in our understanding of class I assembly, anterograde transport and endocytosis and highlight some of the events targeted by viruses as a means to evade detection by cytotoxic T cells and natural killer cells.|Biological Transport[MESH]|Down-Regulation[MESH]|Endocytosis[MESH]|Endoplasmic Reticulum/metabolism[MESH]|Histocompatibility Antigens Class I/*metabolism[MESH]|Humans[MESH]|Ubiquitination[MESH] |