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lüll Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought Rabins P; Appleby BS; Brandt J; DeLong MR; Dunn LB; Gabriels L; Greenberg BD; Haber SN; Holtzheimer PE 3rd; Mari Z; Mayberg HS; McCann E; Mink SP; Rasmussen S; Schlaepfer TE; Vawter DE; Vitek JL; Walkup J; Mathews DJArch Gen Psychiatry 2009[Sep]; 66 (9): 931-7CONTEXT: A 2-day consensus conference was held to examine scientific and ethical issues in the application of deep brain stimulation for treating mood and behavioral disorders, such as major depression, obsessive-compulsive disorder, and Tourette syndrome. OBJECTIVES: The primary objectives of the conference were to (1) establish consensus among participants about the design of future clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and (2) develop standards for the protection of human subjects participating in such studies. RESULTS: Conference participants identified 16 key points for guiding research in this growing field. CONCLUSIONS: The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures. That said, the adoption of the guidelines will require broad and substantial commitment from many of these same stakeholders.|Clinical Trials as Topic/*ethics/methods[MESH]|Deep Brain Stimulation/*ethics/methods[MESH]|Depressive Disorder/therapy[MESH]|Ethics, Research[MESH]|Humans[MESH]|Mental Disorders/*therapy[MESH]|Obsessive-Compulsive Disorder/therapy[MESH]|Tourette Syndrome/therapy[MESH] |