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lüll Stonins--specialized adaptors for synaptic vesicle recycling and beyond?Maritzen T; Podufall J; Haucke VTraffic 2010[Jan]; 11 (1): 8-15Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves as a linker between the endocytic proteins AP-2 and Eps15 and the calcium-sensing synaptic vesicle (SV) protein synaptotagmin 1. The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin 2 are evolutionarily conserved from worm to man, thereby identifying stonin 2 and its invertebrate homologs uncoordinated (UNC)-41 and stoned B as endocytic adaptors dedicated to the retrieval of surface-stranded SV proteins, most notably synaptotagmin. In this review, we summarize the current state of knowledge about mammalian stonins with a special focus on the role of stonin 2 in SV recycling at presynaptic nerve terminals.|Adaptor Protein Complex mu Subunits/chemistry/metabolism/*physiology[MESH]|Adaptor Proteins, Vesicular Transport[MESH]|Animals[MESH]|Endocytosis/physiology[MESH]|Humans[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Presynaptic Terminals/metabolism/physiology[MESH]|Protein Structure, Tertiary[MESH]|Protein Transport[MESH]|Structural Homology, Protein[MESH]|Synaptic Vesicles/metabolism/*physiology[MESH]|Synaptotagmin I/chemistry/metabolism/physiology[MESH]|Vesicular Transport Proteins/chemistry/metabolism/physiology[MESH] |