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A decade of molecular pathogenomic analysis of group A Streptococcus Musser JM; Shelburne SA 3rdJ Clin Invest 2009[Sep]; 119 (9): 2455-63Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated a systems biology investigative strategy designed to enhance and accelerate our understanding of disease processes. Here, we provide examples of the progress made by exploiting an integrated genome-wide research platform to gain new insight into molecular pathogenesis. The studies have provided many new avenues for basic and translational research.|Gene Transfer, Horizontal[MESH]|Genome, Bacterial[MESH]|Genome-Wide Association Study[MESH]|Genomics[MESH]|Host-Pathogen Interactions[MESH]|Humans[MESH]|Molecular Epidemiology[MESH]|Streptococcal Infections/epidemiology/etiology/microbiology[MESH]|Streptococcal Vaccines/isolation & purification[MESH]|Streptococcus pyogenes/*genetics/*pathogenicity[MESH]|Systems Biology[MESH]|Virulence Factors/biosynthesis/genetics[MESH]|Virulence/genetics[MESH] |
