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lüll Paraspeckles: nuclear bodies built on long noncoding RNA Bond CS; Fox AHJ Cell Biol 2009[Sep]; 186 (5): 637-44Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-epsilon/beta), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA.|Animals[MESH]|Cell Nucleus/metabolism/ultrastructure[MESH]|DNA-Binding Proteins[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Intranuclear Inclusion Bodies/*genetics/metabolism[MESH]|Nuclear Matrix-Associated Proteins/genetics/metabolism[MESH]|Nuclear Proteins/genetics/metabolism[MESH]|Octamer Transcription Factors/genetics/metabolism[MESH]|PTB-Associated Splicing Factor[MESH]|RNA, Untranslated/genetics/*metabolism[MESH]|RNA-Binding Proteins/genetics/metabolism[MESH] |