Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors Bruchas MR; Land BB; Chavkin CBrain Res 2010[Feb]; 1314 (ä): 44-55Stress is a complex experience that carries both aversive and motivating properties. Chronic stress causes an increase in the risk of depression, is well known to increase relapse of drug seeking behavior, and can adversely impact health. Several brain systems have been demonstrated to be critical in mediating the negative affect associated with stress, and recent evidence directly links the actions of the endogenous opioid neuropeptide dynorphin in modulating mood and increasing the rewarding effects of abused drugs. These results suggest that activation of the dynorphin/kappa opioid receptor (KOR) system is likely to play a major role in the pro-addictive effects of stress. This review explores the relationship between dynorphin and corticotropin-releasing factor (CRF) in the induction of dysphoria, the potentiation of drug seeking, and stress-induced reinstatement. We also provide an overview of the signal transduction events responsible for CRF and dynorphin/KOR-dependent behaviors. Understanding the recent work linking activation of CRF and dynorphin/KOR systems and their specific roles in brain stress systems and behavioral models of addiction provides novel insight to neuropeptide systems that regulate affective state.|Animals[MESH]|Brain/metabolism/*physiopathology[MESH]|Comorbidity[MESH]|Corticotropin-Releasing Hormone/physiology[MESH]|Dynorphins/*physiology[MESH]|Humans[MESH]|Mood Disorders/chemically induced/metabolism/physiopathology[MESH]|Receptors, Corticotropin-Releasing Hormone/physiology[MESH]|Receptors, Opioid, kappa/*physiology[MESH]|Recurrence[MESH]|Stress, Psychological/metabolism/*physiopathology[MESH]|Substance-Related Disorders/metabolism/*physiopathology[MESH] |
