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lüll PSGL-1-dependent myeloid leukocyte activation Zarbock A; Muller H; Kuwano Y; Ley KJ Leukoc Biol 2009[Nov]; 86 (5): 1119-24Cell-cell interactions mediating leukocyte recruitment and inflammation are crucial for host defense. Leukocyte recruitment into injured tissue proceeds in a multistep process. The first contact of leukocytes with endothelial cells ("capturing" or "tethering") is mediated by selectins and their counter-receptor P-selectin glyco-protein ligand (PSGL)-1. During capture and rolling, leukocytes collect different inflammatory signals, which can activate various pathways. Integration of these signals leads to leukocyte activation, integrin-mediated arrest, cytoskeleton rearrangement, polarization, and transmigration. PSGL-1 on leukocytes also binds to activated platelets, where P-selectin is expressed at locally high site densities following alpha-granule fusion with the plasma membrane. Here, we review the signaling functions of PSGL-1 and speculate how the different known signaling events might relate to different phases of leukocyte recruitment.|Amino Acid Sequence[MESH]|Animals[MESH]|Blood Platelets/*physiology[MESH]|Cell Adhesion/physiology[MESH]|Cell Communication/physiology[MESH]|Humans[MESH]|Inflammation/*blood/*physiopathology[MESH]|Integrins/physiology[MESH]|Leukocyte Rolling/physiology[MESH]|Leukocytes/*physiology[MESH]|Membrane Glycoproteins/chemistry/metabolism/*physiology[MESH]|Molecular Sequence Data[MESH]|P-Selectin/blood/physiology[MESH]|Platelet Activation/*physiology[MESH]|Protein Processing, Post-Translational[MESH]|Sequence Alignment[MESH]|Sequence Homology, Amino Acid[MESH]|Signal Transduction[MESH]|Species Specificity[MESH] |