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lüll Immunosuppressive drugs and Tregs: a critical evaluation!De Serres SA; Sayegh MH; Najafian NClin J Am Soc Nephrol 2009[Oct]; 4 (10): 1661-9To define therapeutic strategies that promote tolerance, it is of critical importance to determine the effects of immunosuppressive drugs on regulatory T cells (Tregs). This review discusses the current knowledge about the physiology of Tregs in humans, the role or Tregs in transplantation, and the impact of the different types of immunosuppressive agents on the frequency and functionality of Tregs in in vitro and in vivo systems.|Abatacept[MESH]|Alemtuzumab[MESH]|Animals[MESH]|Antibodies, Monoclonal, Humanized[MESH]|Antibodies, Monoclonal/pharmacology[MESH]|Antibodies, Neoplasm/pharmacology[MESH]|Calcineurin Inhibitors[MESH]|Humans[MESH]|Immunoconjugates/pharmacology[MESH]|Immunosuppressive Agents/*pharmacology[MESH]|Mycophenolic Acid/analogs & derivatives/pharmacology[MESH]|Organ Transplantation[MESH]|Sirolimus/pharmacology[MESH]|T-Lymphocytes, Regulatory/*drug effects/physiology[MESH] |