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Clinical trajectories and biological features of primary progressive aphasia (PPA) Rogalski EJ; Mesulam MMCurr Alzheimer Res 2009[Aug]; 6 (4): 331-6Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome characterized by a gradual dissolution of language, but relative sparing of other cognitive domains during the initial stages of the disease. Research has led to substantial progress in understanding the clinical characteristics, genetics, and neuropathology of this syndrome. This article reviews the clinical criteria for diagnosing PPA, discusses the utility of defining the mild cognitive impairment (MCI) stage of PPA, and highlights some of the more recent research advances particularly in the area of pathology and genetics.|*Disease Progression[MESH]|Aphasia, Primary Progressive/*diagnosis/pathology/physiopathology[MESH]|Atrophy/pathology[MESH]|Brain/*pathology[MESH]|Humans[MESH]|Severity of Illness Index[MESH] |
