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lüll The pleiotropic role of the fibrinogen gamma chain in hemostasis Uitte de Willige S; Standeven KF; Philippou H; Ariens RABlood 2009[Nov]; 114 (19): 3994-4001A fraction of fibrinogen contains a differently spliced gamma chain called gamma', which presents itself mainly as heterodimer with the common gammaA chain as gammaA/gamma' fibrinogen. The gamma' chain differs from the gammaA chain in its C-terminus and has important functional implications for fibrinogen. The presence of the gamma' chain modulates thrombin and FXIII activity, influences clot architecture, and eliminates a platelet-binding site. Associations of gammaA/gamma' fibrinogen levels with arterial and venous thrombosis have been reported, indicating that the functional effects of gammaA/gamma' fibrinogen may contribute to the pathology of thrombosis. This review summarizes the key biologic aspects of this interesting variant of fibrinogen and discusses inconsistencies in current reports.|Alternative Splicing[MESH]|Amino Acid Sequence[MESH]|Dimerization[MESH]|Factor XIII/metabolism[MESH]|Fibrinogens, Abnormal/chemistry/genetics/*physiology/ultrastructure[MESH]|Hemostasis/genetics/*physiology[MESH]|Humans[MESH]|Microscopy, Electron, Scanning[MESH]|Molecular Sequence Data[MESH]|Platelet Aggregation[MESH]|Protein Structure, Quaternary[MESH]|Recombinant Proteins/chemistry/genetics/metabolism/ultrastructure[MESH]|Risk Factors[MESH]|Thrombin/metabolism[MESH]|Thrombosis/blood/etiology[MESH] |