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lüll Clinical experience with aurora kinase inhibitors: a review Boss DS; Beijnen JH; Schellens JHOncologist 2009[Aug]; 14 (8): 780-93The aurora kinase family of serine/threonine kinases comprises three members, designated auroras A, B, and C. Auroras A and B are essential components of the mitotic pathway, ensuring proper chromosome assembly, formation of the mitotic spindle, and cytokinesis. The role of aurora C is less clear. Overexpression of aurora A and B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. Several small molecules targeting aurora kinases A and B or both have been evaluated preclinically and in early phase I trials. In this review we aim to summarize the most recent advances in the development of aurora kinase inhibitors, with a focus on the clinical data.|Animals[MESH]|Aurora Kinase C[MESH]|Aurora Kinases[MESH]|Humans[MESH]|Neoplasms/therapy[MESH]|Protein Kinase Inhibitors/chemistry/*pharmacology/therapeutic use[MESH]|Protein Serine-Threonine Kinases/*antagonists & inhibitors/metabolism[MESH] |